You do you, and I do me means that if two people are arguing about something and do not reach a consensus, they agree that each should do what’s best for them.

Also possible: I do me, and you do you./You do you.

e.g., I disagree with you and won’t change my opinion, so you do you, and I do me.

-Bob, do you really think that’s the right thing to do?

-Yes, I do.

-Well, I don’t, so you do you, and I do me.

Tradução: Você faz o que você quer, e eu faço o que eu quero. Cada um na sua.