To hit the road means to leave, especially to return home, or to depart on a journey.
For example:
We have to hit the road very early in the morning.
It’s getting kind of late, so I think I’m going to hit the road.
We plan to hit the road around 7:00 a.m. tomorrow, so we can arrive in New York in time for dinner.
I’d love to stay longer, but it’s really time to hit the road.
I was relieved to get back in the car and hit the road again.
Tradução: pegar a estrada, ir nessa, partir.
Listen to the song Hit the Road by Ray Charles.
Eliane Rabello 
Great
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